文章基本信息

标题：Many ABCs make light work with cholesterol
本地全文：下载
作者：Dmitri Sviridov
期刊名称：Aging
出版年度：2013
卷号：5
期号：9
页码：637-638
出版社：U.S.Department of Health & Human Service
摘要：Cholesterol-centric model of the Universe is gaining recognition. The key role of cholesterol metabolism in cardiovascular diseases has been accepted long ago; emerging evidence now supports the central role of cholesterol metabolism in neurodegenerative, metabolic, skin and infectious diseases. Cellular cholesterol content has to be maintained within tight limits, or else; not surprisingly, therefore, a number of regulatory mechanisms provide multi-layer protection of cholesterol homeostasis. Deficiency of cholesterol is rarely an issue: all human nucleated cells have efficient cholesterol biosynthesis machinery capable of satisfying the need in cholesterol under almost any circumstance. Excess of cholesterol is a different matter, it almost inevitably causes severe pathology with clinical manifestation depending on the tissue affected. Difficulty is withstanding excessive cholesterol is because the only cell type capable of degrading cholesterol is hepatocyte; other cells and tissues have to find a way around it. Reducing production of cholesterol and its uptake from lipoproteins provide some relief, but can only go so far. Esterification of cholesterol, although reduces toxicity, is nevertheless a trap as reversing it (hydrolysis of cholesteryl esters) is a very slow process. The most important regulatory pathway in maintaining cholesterol homeostasis is therefore reverse cholesterol transport (RCT)