文章基本信息

标题：Ambient Air Pollution and Autism in Los Angeles County, California
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作者：Tracy Ann Becerra ; Michelle Wilhelm ; Jørn Olsen 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2013
卷号：121
期号：3
页码：380-386
DOI：10.1289/ehp.1205827
出版社：OCR Subscription Services Inc
摘要：Ba c k g r o u n d: The prevalence of autistic disorder (AD), a serious developmental condition, has risen dramatically over the past two decades, but high-quality population-based research addressing etiology is limited.oB j e c t i v e s: We studied the influence of exposures to traffic-related air pollution during pregnancy on the development of autism using data from air monitoring stations and a land use regression (LUR) model to estimate exposures.Me t h o d s: Children of mothers who gave birth in Los Angeles, California, who were diagnosed with a primary AD diagnosis at 3–5 years of age during 1998–2009 were identified through the California Department of Developmental Services and linked to 1995–2006 California birth certifi-cates. For 7,603 children with autism and 10 controls per case matched by sex, birth year, and mini-mum gestational age, birth addresses were mapped and linked to the nearest air monitoring station and a LUR model. We used conditional logistic regression, adjusting for maternal and perinatal characteristics including indicators of SES.re s u l t s: Per interquartile range (IQR) increase, we estimated a 12–15% relative increase in odds of autism for ozone [odds ratio (OR) = 1.12, 95% CI: 1.06, 1.19; per 11.54-ppb increase] and par-ticulate matter ≤ 2.5 μm (OR = 1.15; 95% CI: 1.06, 1.24; per 4.68-μg/m3increase) when mutually adjusting for both pollutants. Furthermore, we estimated 3–9% relative increases in odds per IQR increase for LUR-based nitric oxide and nitrogen dioxide exposure estimates. LUR-based associa-tions were strongest for children of mothers with less than a high school education.co n c l u s i o n: Measured and estimated exposures from ambient pollutant monitors and LUR model suggest associations between autism and prenatal air pollution exposure, mostly related to traffic sources
关键词：air pollution; autism; land-use regression; pregnancy; traffic. Environ Health Perspect