文章基本信息

标题：THE POTENTIAL ADVANTAGES OF NANOTECHNOLOGY IN ANAPLASMOSIS THERAPEUTICS: PREPARATION OF OXYTETRACLINE-LOADED PMMA NANOPARTICLES FOR ORAL DELIVERY
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作者：PRAKASH. K. B ; MADHUSUDHAN. B ; BHAGYALAKSHMI.M 等
期刊名称：Indian Streams Research Journal
印刷版ISSN：2230-7850
出版年度：2013
卷号：III
期号：II
出版社：Indian Streams Research Journal
摘要：In recent days, nanoparticles-based drug delivery systems have considerable potential for treatment of several infectious diseases. The concept of nanoscale devices has led to the development of biodegradable self-assembled nanoparticles being engineered for the targeted delivery of therapeutic molecules. Biodegradable nanoparticulate carriers have become the promising nanoscale drug delivery system. The aim of the present investigation was to formulate and characterize the Oxytetracycline-loaded polymeric nanoparticles. Oxytetracycline, an antianaplasmic agent, was encapsulated by the nanoprecipitation method using poly(methyl methacrylate). Zeetasizer, Atomic force microscope, differential scanning calorimetry and FTIR were used to characterize the nanoparticles. The average diameters of the nanoparticles ranged between 200-250nm and the zeta potential was -32 mV. The drug loading capacity and loading efficiency of nanoparticles varied between 33.7% - 72.2% and 44.5% - 76.0%. The release profiles exhibited a biphasic phenomenon indicating controlled release of drug. The investigation suggests that the resultant nanoparticles would promise to be a good candidate for oral administration.
关键词：Oxytetracycline;Nanoprecipitation;PMMA nanoparticles;Controlled release