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标题：8-Weeks of β-GPA Treatment Reduces Body Mass While Positively Altering Translation Initiation in Obese Skeletal Muscle
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作者：Joshua C. Drake ; Lauryn Benninger ; David L. Williamson 等
期刊名称：Obesity & Weight Loss Therapy
电子版ISSN：2165-7904
出版年度：2011
卷号：1
期号：1
页码：101-101
DOI：10.4172/2165-7904.1000101
出版社：OMICS Group
摘要：The aim of this study was to determine how 3-guanidinopropionic acid (ß-GPA) treatment, that reduces body mass, alters obese skeletal muscle mass and regulatory mechanisms controlling muscle mass. Lean (L) and ob/ob (O) mice were fed either a control (C) or a ß-GPA-containing (F) diet for 8 weeks. Body mass decreased in both ß-GPA treated groups. Despite a lower plantar flexor-complex muscle mass, both ß-GPA treated groups achieved the same muscle mass. Raptor-mammalian Target of Rapamycin protein association was lower in OC muscle (vs. LC) and was not altered with ß-GPA, despite reductions in S6K1 activation (OF only). 4E-BP1 phosphorylation increased in the ß-GPA treated groups, but only the OF mice displayed an increase in eIF4E phosphorylation that corresponded with a trending increase in eIF4G-eIF4E association. Thus, long-term ß-GPA treatment augments obesity-induced dysregulation of mechanisms controlling skeletal muscle mass to that of the lean, while reducing body mass.
关键词：Translational control; eIF4E; 4E-BP1; mTOR; ob/ob