文章基本信息

标题：A Type-C Virus in Human Rhabdomyosarcoma Cells After Inoculation into NIH Swiss Mice Treated with Antithymocyte Serum
本地全文：下载
作者：George J. Todaro ; Paul Arnstein ; Wade P. Parks 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：3
页码：859-862
DOI：10.1073/pnas.70.3.859
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A type-C RNA virus has been isolated that replicates readily in human and other primate cells. It was obtained from a human rhabdomyosarcoma cell (RD) that had been serially transplanted in immunosuppressed NIH Swiss mice, a strain of mouse from which infectious type-C virus has not been isolated. Various other human tumor cells, similarly transplanted, remained free of overt type-C virus expression. The virus growing in the RD cells, AT-124, has a group-specific antigen and an RNA-dependent DNA polymerase immunologically related to murine type-C viruses, but a host range similar to that of the RD-114 virus. The new isolate is either a previously undescribed, endogenous type-C virus from NIH Swiss mice or a recombinant with both mouse and human type-C genetic information.
关键词：RNA-dependent DNA polymerase ; group-specific antigen