文章基本信息

标题：Implications of TL Phenotype Changes in an H-2-Loss Variant of a Transplanted H-2b/H-2a Leukemia
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作者：Edward A. Boyse ; Elisabeth Stockert ; Chika A. Iritani 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1970
卷号：65
期号：4
页码：933-938
DOI：10.1073/pnas.65.4.933
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：An H-2-loss variant line, lacking H-2a antigens, was obtained from an H-2b/H-2a (C57BL x A)F1 transplanted leukemia by immunoselection. The TL phenotype of the unselected line was TL.1,2,3,4 and that of the variant TL.1,2,4, which is the phenotype of TL+ leukemias of C57BL. This finding, and the observed quantitative alterations of antigens TL.1,2 and 4, indicate that the Tla (Thymus leukemia antigen) locus was functionally deleted together with the H-2 locus in the process of variant formation, despite absence of selection against cells carrying TL antigens. Representation of H-2 antigens of the remaining haplotype, H-2b, was quantitatively unchanged.