文章基本信息

标题：Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway
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作者：Tory Herman ; H. Robert Horvitz
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：3
页码：974-979
DOI：10.1073/pnas.96.3.974
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have molecularly analyzed three genes, sqv-3, sqv-7, and sqv-8, that are required for wild-type vulval invagination in Caenorhabditis elegans. The predicted SQV-8 protein is similar in sequence to two mammalian {beta}(1,3)-glucuronyltransferases, one of which adds glucuronic acid to protein-linked galactose-{beta}(1,4)-N-acetylglucosamine. SQV-3 is similar to a family of glycosyltransferases that includes vertebrate {beta}(1,4)-galactosyltransferases, which create galactose-{beta}(1,4)-N-acetylglucosamine linkages. One model is therefore that SQV-8 uses a SQV-3 product as a substrate. SQV-7 is similar to members of a family of nucleotide-sugar transporters. The sqv genes therefore are likely to encode components of a conserved glycosylation pathway that assembles a C. elegans carbohydrate moiety, the absence of which perturbs vulval invagination.