文章基本信息

标题：sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination
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作者：Tory Herman ; Erika Hartwieg ; H. Robert Horvitz 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：3
页码：968-973
DOI：10.1073/pnas.96.3.968
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：By screening for mutations that perturb the invagination of the vulva of the Caenorhabditis elegans hermaphrodite, we have isolated 25 mutations that define eight genes. We have named these genes sqv-1 to sqv-8 (squashed vulva). All 25 mutations cause the same vulval defect, an apparent partial collapse of the vulval invagination and an elongation of the central vulval cells. Most sqv mutations also cause an oocyte or somatic gonad defect that results in hermaphrodite sterility, and some sqv mutations cause maternal-effect lethality. We propose that the sqv genes affect a pathway common to vulval invagination, oocyte development, and embryogenesis.