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标题：Mast cells enhance T cell activation: Importance of mast cell-derived TNF
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作者：Susumu Nakae ; Hajime Suto ; Maki Kakurai 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2005
卷号：102
期号：18
页码：6467-6472
DOI：10.1073/pnas.0501912102
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by Fc{epsilon}RI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production.
关键词：allergy ; asthma ; autoimmunity ; cytokines ; immune response