Reaction of 2-amino-4-phenylthiazole with various aromatic aldehydes afforded 2-arylideneamino-4-phenylthiazoles. On the other hand treatment of 2-amino-4-phenylthiazole with several acyl halides furnished N -(thiazol-2-yl)-amides. The synthesized compounds have been screened for their antimicrobial activity against Bacillus cereus , Bacillus subtilis , Staphylococcus aureus, Shigella dysenteriae , Salmonella typhi , Pseudomonous sp. bacteria and Aspergillus niger, Penicillium notatum, Aspergillus funiculosus, Collectrichum corchori Ikata (Yoshida) and Curvularia lunata fungi respectively. Some of the synthesized compounds exhibited pronounced antimicrobial activities.
Keywords : Aminothiazole; Arylideneaminothizole; N -(Thiazol-2-yl)-amide; Antimicrobial activity.
© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.
doi:10.3329/jsr.v3i1.5419 J. Sci. Res. 3 (1), 111-119 (2011)