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标题：Benzoylation of Thiosemicarbazide
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作者：A.A. Creanga ; V.N. Bercean ; V. Badea 等
期刊名称：Universitatea Politehnica din Timisoara. Buletinul Stiintific. Seria Chimie si Ingineria Mediului
印刷版ISSN：1224-6018
出版年度：2008
卷号：53(67)
期号：01-02
出版社：Universitatea Politehnica din Timisoara
摘要：Benzoylation of 1-benzoyl-thiosemicarbazide (2) or dibenzoylation of thiosemicarbazide (1) with benzoyl chloride, in the presence of pyridine, gave a mixture of 1,2-dibenzoyl-thiosemicarbazide (4) and 1,4-dibenzoyl-thiosemicarbazide (5). Treating the mixture of isomers with Na2CO3 5% solution, at boiling temperature, gave 4 H -5-mercapto-3-phenyl-1,2,4-triazole (3) (and not 4 H -4-benzoyl-5-mercapto-3-phenyl-1,2,4-triazole (6), as it was expected), formed from 1,4-dibenzoyl-thiosemicarbazide, and 1,2-dibenzoyl-hydrazine (8), formed from 1,2-dibenzoyl-thiosemicarbazide. The structure of the isomeric 1,4-dibenzoyl-thiosemicarbazide was confirmed by IR and NMR spectroscopy.
关键词：4 H -5-mercapto-3-phenyl-1,2,4-triazole, dibenzoyl-thiosemicarbazide, cyclisation