文章基本信息

标题：GM-CSF: A Promising Target in Inflammation and Autoimmunity
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作者：Kevin MC Lee ; Adrian A Achuthan ; John A Hamilton 等
期刊名称：ImmunoTargets and Therapy
电子版ISSN：2253-1556
出版年度：2020
卷号：9
页码：225-240
DOI：10.2147/ITT.S262566
出版社：Dove Medical Press Ltd
摘要：The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and differentiation of bone marrow progenitors into granulocytes and macrophages. Much preclinical data have indicated that GM-CSF has a wide range of functions across different tissues in its action on myeloid cells, and GM-CSF deletion/depletion approaches indicate its potential as an important therapeutic target in several inflammatory and autoimmune disorders, for example, rheumatoid arthritis. In this review, we discuss briefly the biology of GM-CSF, raise some current issues and questions pertaining to this biology, summarize the results from preclinical models of a range of inflammatory and autoimmune disorders and list the latest clinical trials evaluating GM-CSF blockade in such disorders.
关键词：GM-CSF;inflammation;autoimmunity;therapeutic