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标题：Antioxidant activity and mechanism of inhibitory action of gentisic and α-resorcylic acids
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作者：Azadeh Mardani-Ghahfarokhi ; Reza Farhoosh
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2020
卷号：10
期号：1
页码：1-11
DOI：10.1038/s41598-020-76620-2
出版社：Springer Nature
摘要：The antioxidant activity of gentisic (GA) and α-resorcylic (α-RA) acids was investigated by considering their molecular structures in various oxidative environments, including DPPH· scavenging assay, stripped olive and soybean oils, and the corresponding oil-in-water emulsions. The mechanism of action in the oils was evaluated in the presence of different concentrations of the antioxidants at 60 °C, using the kinetic parameters the stabilization factor (F), the oxidation rate ratio (ORR), the activity (A), and the average rate of antioxidant consumption ( $$\overline{r}_{{{\text{AH}}}}$$ ). GA was significantly more potent antioxidant than α-RA in all the environments. Although the less polar α-RA showed better activity in the emulsions rather than in the bulk oils, GA with an ortho-hydroxy structure had higher capacity to scavenge DPPH·, and LOO· in the oils and emulsions. The lower performance of α-RA was attributed to its participation in side reactions of chain initiation (AH LOOH → A· L· H2O) and propagation (A· LH → AH L·) as competed with the main chain termination reaction (LOO· AH → LOOH A·).
其他摘要：Abstract The antioxidant activity of gentisic (GA) and α-resorcylic (α-RA) acids was investigated by considering their molecular structures in various oxidative environments, including DPPH · scavenging assay, stripped olive and soybean oils, and the corresponding oil-in-water emulsions. The mechanism of action in the oils was evaluated in the presence of different concentrations of the antioxidants at 60 °C, using the kinetic parameters the stabilization factor ( F ), the oxidation rate ratio (ORR), the activity ( A ), and the average rate of antioxidant consumption ( $$\overline{r}_{{{\text{AH}}}}$$ r ¯ AH ). GA was significantly more potent antioxidant than α-RA in all the environments. Although the less polar α-RA showed better activity in the emulsions rather than in the bulk oils, GA with an ortho -hydroxy structure had higher capacity to scavenge DPPH · , and LOO · in the oils and emulsions. The lower performance of α-RA was attributed to its participation in side reactions of chain initiation (AH LOOH → A · L · H 2 O) and propagation (A · LH → AH L · ) as competed with the main chain termination reaction (LOO · AH → LOOH A · ).