文章基本信息

标题：Optimazation of the Assement and Apoptosis of Endocrine- Bisphenol A Disruptors
其他标题：내분비계장애물질 평가방법의 최적화 및 Aptjptosis에 관한 연구
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作者：Kwang- Hyun Ahn ; Kyung- A Lee ; Bong- Hee Kim 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2004
卷号：19
期号：3
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Xenoestrogens are chemmcals with diverse structure that mmc estrogen Bisphenol A. a monomer of polyearbonale and epoxy resins,has been detected in canned food and human slva Bisphenol A stmulate cell prolferaton dand Induce expression of estrogen - respone genes in vitro The purpose of the this study was 10 evaluate cell prloferaton of bisphenol A In the presence ot a rat liver S9 mix contaning cytochrome P450 enzymes and Cu(ID) The fragmenaton of Intuct DNA. a parameter of apoptoue cell death,war evaluated quntatively by dphenylamune reaction method Bisphenol A Induced spoptotic cell death In a dore - dependent manner The effect of ruducal cavenger on the apoptotec cell death induced bsphenol A was investngated The DNA trygmentauon Induced by bisphenol A was signficantly inhubrted by sdduton of radical scavenger to the culure medum This indcated thul elevated oxndatie ste cauved by 1mbalance between the producton and remotal of free radeals occurred 1n cells Taken together, these results suggest that free radhcal reacts wuth Cu (I) leading oxuatuve stress.
关键词：Bisphenol A Cell prolferation;DNA trugmentation