文章基本信息

标题：Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018)
本地全文：下载
作者：Ewa Gorodkiewicz ; Zenon Lukaszewski
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2018
卷号：8
期号：4
页码：132-149
DOI：10.3390/bios8040132
出版社：MDPI Publishing
摘要：More than 50 papers on surface plasmon resonance biosensors, published between 2016 and mid-2018, are reviewed. Papers concerning the determination of large particles such as vesicles, exosomes, cancer cells, living cells, stem cells, and microRNA are excluded, as these are covered by a very recent review. The reviewed papers are categorized into five groups, depending on the degree of maturity of the reported solution; ranging from simple marker detection to clinical application of a previously developed biosensor. Instrumental solutions and details of biosensor construction are analyzed, including the chips, receptors, and linkers used, as well as calibration strategies. Biosensors with a sandwich structure containing different nanoparticles are considered separately, as are SPR (Surface Plasmon Resonance) applications for investigating the interactions of biomolecules. An analysis is also made of the markers determined using the biosensors. In conclusion, there is shown to be a growing number of SPR applications in the solution of real clinical problems.
关键词：surface plasmon resonance; cancer markers; biosensors; receptor immobilization; antibodies; nanoparticles surface plasmon resonance ; cancer markers ; biosensors ; receptor immobilization ; antibodies ; nanoparticles