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标题：Australian Gonococcal Surveillance Programme annual report, 2015
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作者：Monica M Lahra ; Rodney P Enriquez
期刊名称：Communicable Diseases Intelligence
印刷版ISSN：1447-4514
电子版ISSN：1445-4866
出版年度：2017
卷号：41
期号：1
页码：E60-E67
出版社：Government Department of Health and Ageing
摘要：The Australian Gonococcal Surveillance Programme(AGSP) has continuously monitored antimicrobialresistance in clinical isolates of Neisseria gonorrhoeaefrom all Australian states and territoriessince 1981. In 2015, there were 5,411 clinical isolatesof gonococci from public and private sectorsources tested for in vitro antimicrobial susceptibilityby standardised methods. Current treatment recommendationsfor the majority of Australian statesand territories is a dual therapeutic strategy of ceftriaxoneand azithromycin. Decreased susceptibilityto ceftriaxone (minimum inhibitory concentration orMIC value 0.06–0.125 mg/L) was found nationallyin 1.8% of isolates, which was lower than thatreported in the AGSP annual report 2014 (5.4%).The highest proportions were reported from SouthAustralia and New South Wales (3.6% and 2.7%respectively). High level resistance to azithromycin(MIC value ≥ 256 mg/L) was again reported in2015, with 1 strain in each of New South Wales andurban Western Australia. There was no reportedAzithromycin resistance in the Australian CapitalTerritory, the Northern Territory, or remote WesternAustralia. The proportion of strains resistant topenicillin in urban and rural Australia ranged from8.7% in Tasmania to 33% in the Australian CapitalTerritory. In rural and remote Northern Territory,penicillin resistance rates remain low (2.2%). Inremote Western Australia relatively low numbersof strains are available for testing, however thereis now widespread molecular testing for penicillinresistance in Western Australia to monitor resistanceand inform guidelines and these data are includedin the AGSP annual report. Quinolone resistanceranged from 11% in the urban and rural areas ofthe Northern Territory, to 41% in South Australia.Quinolone resistance rates remain comparativelylow in remote areas of the Northern Territory (3.3%)and remote areas of Western Australia (3.4%). Therewas no reported quinolone resistance in Tasmania,but the number of isolates tested was relativelylow. Azithromycin resistance ranged from 1.8% inVictoria to 5.8% in Queensland.
关键词：antimicrobial resistance; disease;surveillance; gonococcal infection; Neisseria;gonorrhoeae