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标题：Occurrence of BK Virus and Human Papilloma Virus in colorectal cancer
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作者：Adrian Jarzyński ; Przemysław Zając ; Remigiusz Żebrowski 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：3
页码：440-445
DOI：10.26444/aaem/74648
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Colorectal cancer is one of the most common cancers worldwide. In Poland, it is the secondmost common cancer, regardless of gender. The aim of study was to analyze the incidence of HPV and BKV in the tissue ofcolorectal cancer and to determine the relationship between the presence of these viruses and the development of thiscancer.Materials and method. The experiments were conducted using 50 colorectal cancer tissues collected from histologicalsections. The clinical material was embedded in paraffin blocks. Next, DNA extraction was performed. Isolates of colorectalcancer tissue were tested for the presence of HPV DNA. BKV DNA was detected by PCR using specific primers and thendifferentiated from JCV by digestion with BamHI enzyme.Results. In clinical specimens taken from patients with colorectal cancer, HPV DNA was detected in 20% of cases. In 10%of cases the presence of HPV type 18 was confirmed, in the other 90% of the samples HPV type 16 was detected, while thepresence of BKV was confirmed in 30% of cases. Coinfection with HPV and BKV was shown in 12% of patients. In one case,BK virus coexisted with HPV type 18, in the remaining 5 cases with HPV type 16.Conclusions. Developing colorectal cancer can show no symptoms, even for many years. This is why it is so important tobecome familiar with as many etiological factors as possible. The development of many human neoplasms is often initiatedby exposure to infectious agents – such as bacterial or viral infections. Similar to the human papillomavirus, the BK viruswas detected in clinical specimens. It seems that HPV and BKV infections can contribute to the neoplastic process, whichrequires detailed studies on a larger group of patients.
关键词：BKV; HPV; colorectal cancer.