文章基本信息

标题：5-Azacytidine induction of mouse endogenous type C virus and suppression of DNA methylation
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作者：O Niwa ; T Sugahara
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：10
页码：6290-6294
DOI：10.1073/pnas.78.10.6290
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：5-Azacytidine was found to induce the expression of BALB:virus-1 and BALB:virus-2 from K-BALB cells and ecotropic endogenous virus from AKR2B cells. Efficiency of the induction was high and comparable to that by 5-bromodeoxyuridine. The level of methylcytosine in newly synthesized DNA was drastically decreased when K-BALB cells were treated with 5-azacytidine. There was an inverse relationship between the level of DNA modification and the frequency of virus expression.