文章基本信息

标题：Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes
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作者：P S Sunkara ; D A Wright ; P N Rao 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1979
卷号：76
期号：6
页码：2799-2802
DOI：10.1073/pnas.76.6.2799
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cytoplasmic extracts of HeLa cells synchronized in various phases of the cell cycle were injected into fully grown Xenopus laevis oocytes to monitor the presence of factors that can induce meiotic maturation: i.e., germinal vesicle breakdown and chromosome condensation. Extracts from GI and S phase cells had no activity. The maturation-inducing activity, which was found to be low during early and mid G2 phases, increased rapidly during late G2 and reached a peak in mitosis. The results of this study suggest that the factors that regulate the breakdown of nuclear membrane and chromosome condensation during mitosis, meiosis, and premature chromosome condensation appear to be very similar, if not identical, throughout the animal kingdom.