文章基本信息

标题：Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells
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作者：Verónica A. Burzio ; Claudio Villota ; Jaime Villegas 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：23
页码：9430-9434
DOI：10.1073/pnas.0903086106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.
关键词：differential expression in cancer ; RNAs with stem-loop structures