文章基本信息

标题：A concise, total synthesis of the TMC-95A/B proteasome inhibitors
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作者：Brian K. Albrecht ; Robert M. Williams
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：33
页码：11949-11954
DOI：10.1073/pnas.0308432101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A concise, total synthesis of the proteasome inhibitors TMC-95A/B has been accomplished. The synthesis features the use of an L-serine-derived E-selective modified Julia olefination reaction to ultimately control the stereochemical outcome of the highly oxidized tryptophan fragment. Additionally, the limited use of protecting groups at a late stage of the total synthesis allowed for its completion in an efficient manner.
关键词：Julia olefination ; Suzuki biaryl coupling ; Stille coupling