文章基本信息

标题：Late onset muscle plasticity in the whisker pad of enucleated rats
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作者：Brenda Toscano-Márquez ; Eduardo Martínez-Martínez ; Elías Manjarrez 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2008
卷号：105
期号：41
页码：15973-15978
DOI：10.1073/pnas.0808431105
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Blindness leads to a major reorganization of neural pathways associated with touch. Because incoming somatosensory information influences motor output, it is plausible that motor plasticity occurs in the blind. In this work, we evaluated this issue at the peripheral level in enucleated rats. Whisker muscles in enucleated rats 160 days of age or older showed increased cytochrome oxidase activity, capillary density, motor plate size, and amplitude of evoked field potentials as compared with their control counterparts. Such differences were not observed at ages 10 and 60 days, the capillary density was the exception being greater in the enucleated rat at the latter age. Interestingly, there was a trend to increased neurotrophin-3 concentrations in the whisker pads of enucleated rats throughout postnatal development. Our results show that neonatal enucleation leads to late onset plasticity of the whisker's motor system.
关键词：blindness ; metabolic activity ; motor plasticity ; motor plate potentials ; skeletal muscle