文章基本信息

标题：Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity
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作者：Anna Kriebs ; Sabine D. Jordan ; Erin Soto 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：33
页码：8776-8781
DOI：10.1073/pnas.1704955114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER). CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched for NR recognition motifs. Here we report that CRY1/2 serve as corepressors for many NRs, indicating a new facet of circadian control of NR-mediated regulation of metabolism and physiology, and specifically contribute to diurnal modulation of drug metabolism.
关键词：nuclear hormone receptor ; cryptochrome ; circadian ; corepressor ; xenobiotic metabolism