文章基本信息

标题：有機燐製剤による血中コリンエステラーゼの阻害とPAMによる回復(I)
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作者：奥井誠一 ; 渡辺精子 ; 橋本幸子等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1963
卷号：9
期号：2
页码：108-112
DOI：10.1248/jhs1956.9.108
出版社：The Pharmaceutical Society of Japan
摘要：When six organophosphorus compounds of P=S type (Parathion, Methylparathion, Malathon, Ekatin, Baycid and Sumithion) were treated with the oxidative reagent (bromine water), the inhibition of cholinesterase activity by these phosphorus compounds was markedly increased. Similar tendency was found in the case of thiol and sulfoxide type compounds. When these oxidized organophosphorus compounds were present, the reactivation rate of cholinesterase activity by PAM was elevated significantly. In contrast to these inhibitors dimethoate did not show the increased inhibition of cholinesterase activity by the oxidative treatment and in this case the effectiveness of PAM was also unchanged.