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标题：THE CHANGE OF P-AMINOHIPPURIC ACID DISPOSITION KINETICS ACCOMPANIED BY GROWTH IN MICE
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作者：JUNJI HIRATE ; ISAMU HORIKOSHI ; JUN WATANABE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：11
页码：924-930
DOI：10.1248/bpb1978.8.924
出版社：The Pharmaceutical Society of Japan
摘要：The change of disposition kinetics for p-aminohippuric acid (PAH) was studied following intravenous administration of p-[glycyl-1-¹⁴C] aminohippuric acid to 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. The expiratory excretion of ¹⁴CO₂ in 24 h following the administration was almost negligible in 1-day-old and 1-week-old mice in contrast to 3-week-old (6.8±1.8%) and 8-week-old (8.8±1.9%) mice. The ability to metabolize PAH may not be developed in these infant mice.The elimination of blood radioactivity following the administration was considerably delayed in 1-day-old and 1-week-old mice, especially in 1-day-old mice, suggesting that the renal trubular secretory function for PAH might not have been developed in the infant mice. Whole-body autoradiographic data showed that the transfer of PAH form blood to muscle was enhanced in 1-day-old and 1-week-old mice, especially in 1-day-old mice, compared to 3-week-old and 8-week-old mice. The enhanced muscular cell membrane permeability to PAH in 1-day-old and 1-week-old mice was considered to be the most plausible explanation for this result.
关键词：muscular blood flow rate