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标题：Effect of Intraperitoneal Injection with Chlorobenzene on Glutathione Metabolism in Rat Liver
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作者：Munehiro YOSHIDA ; Ichiro HARA
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1984
卷号：22
期号：1
页码：11-21
DOI：10.2486/indhealth.22.11
出版社：National Institute of Occupational Safety and Health
摘要：Effect of chlorobenzene administration on glutathione metabolism in rat liver was investigated. Rats were intraperitoneally injected with chlorobenzene (2.0 mmol/kg). At 6 hours, hepatic total and oxidized glutathione in the rat with chlorobenzene decreased to 24% and 53% of those in control rats without chloro-benzene, respectively. When 24 hours passed after the injection, the total and oxidized glutathione increased to 188% and 170% of the control, respectively. And simultaneously, the activities of hepatic glutathione synthesis and glutathione reductase elevated to 193% and 136% of the control, respectively. At 48 hours, these elevation were still found and the liver was enlarged with significant increase in the protein and DNA. The activities of hepatic γ-glutamyltranspeptidase and glutathione peroxidase were unaltered by the chlorobenzene. Similarly to the single injection, four times intraperitoneal injection with chlorobenzene (2.0 mmol/kg/one shot at 48 hours-intervals) caused the hepatic enlargement and the accumulation of hepatic glutathione. These results indicate that the acceleration of hepatic glutathione synthesis, occurring in response to the transient decrease of glutathione, caused the accumulation of glutathione in liver of rat injected with chlorobenzene.
关键词：Glutathione;Glutathione synthesis;Oxidized glutathione;Glutathione reductase;Chlorobenzene