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标题：Isomerization increases the postprandial oxidation of linoleic acid but not α-linolenic acid in men
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作者：L. Bretillon ; J. M. Chardigny ; J. L. Sébédio 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：6
页码：995-997
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Human lipid intake contains various amounts of trans fatty acids. Refined vegetable and frying oils, rich in linoleic acid and/or α-linolenic acid, are the main dietary sources of trans -18:2 and trans -18:3 fatty acids. The aim of the present study was to compare the oxidation of linoleic acid, α-linolenic acid, and their major trans isomers in human volunteers. For that purpose, TG, each containing two molecules of [1-¹³C]linoleic acid, α-[1-¹³C]linolenic acid, [1-¹³C]-9 cis ,12 trans -18:2, or [1-¹³C]-9 cis ,12 cis ,15 trans -18:3, were synthesized. Eight healthy young men ingested labeled TG mixed with 30 g of olive oil. Total CO₂ production and ¹³CO₂ excretion were determined over 48 h. The pattern of oxidation was similar for the four fatty acids, with a peak at 8 h and a return to baseline at 24 h. Cumulative oxidation over 8 h of linoleic acid, 9 cis, 12 trans -18:2, α-linolenic acid, and 9 cis ,12 cis ,15 trans -18:3 were, respectively, 14.0 ± 4.1%, 24.7 ± 6.7%, 23.6 ± 3.3%, and 23.4 ± 3.7% of the oral load, showing that isomerization increases the postprandial oxidation of linoleic acid but not α-linolenic acid in men. —Bretillon, L., J. M. Chardigny, J. L. Sébédio, J. P. Noël, C. M. Scrimgeour, C. E. Fernie, O. Loreau, P. Gachon, and B. Beaufrère. Isomerization increases the postprandial oxidation of linoleic acid but not α-linolenic acid in men. J. Lipid Res. 2001. 42: 995–997.
关键词：human ; oxidation ; trans fatty acid