文章基本信息

标题：A sterospecific synthesis of 7alpha-hydroxycholesterol.
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作者：D B Johnson ; L Lack
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1976
卷号：17
期号：1
页码：91-93
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The five step synthesis of 7alpha-hydroxycholesterol utilizes the solvolysis of 7alpha-bromocholesterol benzoate with potassium acetate in acetic acid as the key step in controlling the stereospecificity of the reaction sequence. This reaction yields 7alpha-acetoxycholesterol benzoate with retention of configuration at position seven. The diester is readily reduced with lithium aluminum to 7alpha-hydroxycholesterol.