文章基本信息

标题：Liver lipid response to intravenous rare earths in rats
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作者：Fred Snyder ; Edgar A. Cress ; Granvil C. Kyker 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1959
卷号：1
期号：1
页码：125-131
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Intravenous injection of rare earths with low atomic numbers produces fatty infiltration in the liver of rats. This infiltration is maximal 48 hours later and is characterized by an increase in neutral fat esters. Total cholesterol and phospholipids of the liver in cerium-treated rats were similar to those of control livers. Cerium was found to be effective in producing extremely high levels of liver fat in female rats of several strains tested. Male rats treated in the same way did not exhibit the consistent response or the high liver-lipid levels that were seen in the females. After the castration of male rats, their response resembled that of females. Testosterone caused a significant reduction in the fatty infiitration induced by cerium in both intact and ovariectomized females. Hypophysectomy prevented fatty livers in both females and males, whereas adrenalectomy did so only in males. Choline and methionine had no protective effect against cerium. Tracer experiments involving cerium¹⁴⁴ demonstrated that most of the radioactivity appeared in the acid-soluble fraction of the liver and that the lipid fraction contained essentially no tracer.