摘要:The economic modifications along with the rapid demographic growth of the last century have led to the increased significance of effective supply chain management strategies for ensuring food security and safety. Due to the fact that 50% of food produced annually is perishable, the growing and geographically dispersed consumers' demand can only be served through well-designed cold supply networks that manage perishable commodities. The consideration of product perishability in the design of multi-echelon supply chain adds additional complexity to the decision-making process, as time now plays an important role in the preservation of the product's quality. In this respect, responsive supply chains should be developed that employ fast and reliable transportation modes. At the same time, the consideration of the supply chain's environmental impact and economic viability should be also incorporated in the decision-making process. Under this perspective the purposes of this paper are: (i) to identify the parameters, and the distinctive characteristics of supply chains of perishable goods that differentiate them from classical supply networks and raise the need for special managerial capabilities, (ii) to propose a modelling methodology employed for the cost and CO2 emissions optimal design of multi-echelon supply chains, while incorporating the shelf life of the chain’s products in the decision-making process. The applicability of the proposed model is illustrated in the realistic case of a supply chain connecting the South-Eastern with the North-Eastern European regions.