文章基本信息

标题：Antihypertensive drug use during pregnancy: a population based study
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作者：Carmen D'Amore ; Francesco Trotta ; Roberto Da Cas 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2015
卷号：51
期号：3
页码：236-243
DOI：10.4415/ANN_15_03_12
出版社：Editrice Kurtis Srl
摘要：Purpose. The study aimed at assessing if the European guideline on the use of antihypertensivedrugs (AD) in pregnancy are followed in clinical practice. We also evaluated theassociation between the use of non-recommended drugs and individual characteristics.Methods. This study analyzed a cohort of 86 171 singleton deliveries occurring between2009-2010 in the Lombardy region, Italy. Women with first prescription of AD duringpregnancy were considered as incident users. Methyldopa, labetalol and nifedipine wereconsidered as “recommended drugs”; all other AD were considered as “non-recommended”.Odds Ratio and 95% confidence intervals were estimated.Results. Among the 1009 patients (1.2%) exposed to AD during pregnancy, 675 (66.9%)were incident users. Among the incident users, 31% received non-recommended drugs;this proportion decreased to 18% among women who started treatment in the third trimester.Women with at least four concomitant diseases had an elevated risk of receivingnon-recommended drugs in pregnancy (OR 2.68; 95% CI 1.10-6.73).Conclusions. Exposure to recommended antihypertensives increased during pregnancy.Nevertheless, a fraction of users that continued or began treatment with non-recommendedmedications was still present.
关键词：antihypertensive drugs; pregnancy; clinical guidelines