文章基本信息

标题：New insights into thyroid hormone replacement therapy
本地全文：下载
作者：Brenda M Acosta ; Antonio C Bianco
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2010
卷号：2
DOI：10.3410/M2-34
语种：English
出版社：Faculty of 1000 Ltd
摘要：It is widely accepted that thyroid hormone replacement for patients with hypothyroidism can be fully accomplished with levothyroxine monotherapy, as assessed by serum thyroid function tests. However, approximately 10% of hypothyroid patients are dissatisfied with the outcome of levothyroxine monotherapy, and physicians continue to report benefits from combined levothyroxine-triidothyronine therapy for some hypothyroid patients. Recently, a large prospective study reported that the benefit of the combined levothyroxine-triidothyronine therapy is associated with the Thr92Ala polymorphism in the type 2 deiodinase gene, which is present in about 15% of the general population. If confirmed, these findings indicate that personalized medicine is rapidly catching up with modern thyroidology.