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标题：A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age
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作者：Silvia Pérez-Piñero ; Vicente Ávila-Gandía ; Jacobo A. Rubio Arias 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：12
DOI：10.3390/nu13124373
语种：English
出版社：MDPI Publishing
摘要：The aim of a 12-week randomized double-blind placebo-controlled study was to assess the effect of daily supplementation with a natural extract of Spinacia oleracea L. (4 × 500 mg capsules/day; total 2 g per day) combined with a moderate-intensity training program (1 h session/3 times a week) on skeletal muscle fitness in adults over 50 years of age. Muscle strength assessed by isokinetic and isometric dynamometry improved significantly in the experimental ( n = 23) and the placebo ( n = 22) groups, but the magnitude of improvement was higher in the experimental group, with between-group differences in almost all variables, including isokinetic at 60° s −1 in knee extension, peak torque ( p < 0.007); total work per repetition maximum ( p < 0.009); isokinetic at 180°s −1 in knee extension, peak torque ( p < 0.002); total work ( p < 0.007); total work per repetition maximum ( p < 0.005); average power ( p < 0.027); isometric in knee extension, peak torque ( p < 0.005); and average peak torque ( p < 0.002). Similar findings were observed for muscle quality. Changes in quality of life (SF-36) were not found, except for improvements in the role physical ( p < 0.023) and role emotional ( p < 0.001) domains, likely as a result of the physical training sessions. A nutritional survey did not revealed changes in dietary habits. No adverse events were recorded. In subjects over 50 years of age, moderate-intensity strength training combined with daily supplementation for 12 weeks with a natural extract of Spinacia oleracea L. improved muscle-related variables and muscle quality. Maintaining muscle health is a key component of healthy aging.
关键词：natural spinach extract; healthy aging; muscle health; randomized trial; strength training