文章基本信息

标题：Metabolite profiling of Streptomyces sp. Al-Dhabi-100 isolated from the marine environment in Saudi Arabia with anti-bacterial, anti-tubercular and anti-oxidant potentials
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作者：Naif Abdullah Al-Dhabi ; Galal Ali Esmail ; Abdul-Kareem Mohammed Ghilan 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：2
页码：1628-1633
DOI：10.1016/j.jksus.2019.12.021
语种：English
出版社：Elsevier
摘要：AbstractRecently, bioprospecting of marine actinomycetes has attracted because of the exploration of novel metabolites with promising biological applications such antibacterial, antimicobacterial antioxidant. Therefore, the present study has been aimed to explore the isolation and characterization promising marine actinomycetes from the Jazan region of Saudi Arabia and metabolite profiling of the extracellular metabolites together with assessment of anti-bacterial, anti-tubercular and anti-oxidant potentials. The extracellular metabolites were profiled using gas chromatography coupled with mass spectrum and MIC and MBC values of the fractions were evaluated by broth microdilution techniques. Biochemical, micromorphological and 16S rRNA gene analysis study clearly confirmed that the promising strain Al-Dbabi-100 belonged to the genusStreptomyces.MIC values of the fraction noted as 62.5 µg/ml forE. faecalis,31.25 µg/ml forB. subtilis,125 µg/ml forS. aureus,250 µg/ml forS. epidermidisand 125 µg/ml forK. pneumoniaerespectively and cell growth inhibition study resulted 19.78%,71.4% and 91.6% inhibition towardsK. pneumoniae, E. coliandP. aeruginosapathogens. Interestingly, the fraction revealed promising antitubercular and antioxidant activities. GCMS analysis showed 1-(2,6-Dimethyl-4-propoxyphenyl)propan-1-one (7%) and ethyl 2-propylphenyl ester (11.9%) as the major compounds.
关键词：Marine actinomycetes;Antibacterial;Anti-tubercular;Antioxidant