文章基本信息

标题：IDENTIFICATION OF KEY GENES AND PATHWAYS IN GBM THROUGH BIOINFORMATICS ANALYSIS
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作者：Ziheng Wang
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2019
卷号：28
期号：7
页码：5248-5252
语种：English
出版社：PSP Publishing
摘要：Glioblastoma (GBM) is one of the most aggressive malignant glioma in central nervous system. The malignant transformation of GBM results from DNA mutations and alterations in gene expression levels. In this work, we used a bioinformatics approach to investigate the molecular mechanisms of GBM. The gene expression profile of normal genomes was used as a control. The analysis of gene expression revealed important alterations in genes involved in biological processes and metabolic pathways. We also identified some small molecules capable of reversing the altered gene expression in GBM; these molecules could provide a basis for future therapies for the treatment of this disease.
关键词：Glioblastoma;bioinformatics;GEO;malignant;molecular